ISI scientific publications resulted from the project
– Adrian Dumitru, Beatrice Mihaela Radu, Mihai Radu, Sanda Maria Cretoiu ”Muscle Changes During Atrophy”, Advances in Experimental Medicine and Biology (impact factor 2.126), 2018; 1088:73-92. link: https://www.ncbi.nlm.nih.gov/pubmed/30390248
ISI scientific private-public co-publications resulted from the project
– Stefan Mann, Juliane Heide, Razvan Airini, Thomas Knott, Florin Bogdan Epureanu, Alexandru-Florian Deftu, Antonia-Teona Deftu, Beatrice Mihaela Radu, Bogdan Amuzescu, Recording of multiple ion current components and action potentials in human induced pluripotent stem cell-derived cardiomyocytes via automated patch-clamp, Journal of Pharmacological and Toxicological Methods (impact factor 2.679) 2019 Jun 20;100:106599. Link https://www.ncbi.nlm.nih.gov/pubmed/31228558
– Airini Razvan, Iordache Florin, Alexandru Deftu, Savu Lorand, Epureanu Florin, Mihailescu Dan, Amuzescu Bogdan, Maniu Horia. Senescence-induced immunophenotype, gene expression and electrophysiology changes in human amniocytes, Journal of Cellular and Molecular Medicine 2019 Sep 3. doi: 10.1111/jcmm.14495. (impact factor 4.658) link https://www.ncbi.nlm.nih.gov/pubmed/31478614
International patent requests resulted from the project
– Bogdan Amuzescu, Beatrice Mihaela Radu, Dan Florin Mihăilescu, Stefan Mann (2018), ”Method for in vitro detection of the proarrhythmogenic risk of a drug candidate on human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM)”, Patent request at European Patenting Office (EPO), no. EPA18465611.4/24.10.2018, published in the Register of European Patent Office no. EP3546935 / 02.10.2019 (https://register.epo.org/application?number=EP18465611). It was also revendicated the European patent priority to the United States Patent and Trademark Office.
International book chapters resulted from the project
– Bogdan Amuzescu, Horia Maniu, “Molecular and Cellular Biology of the Right Heart”, in cartea Right Heart Pathology, Springer, 2018, DOI 10.1007/978-3-319-73764-5, link https://www.springer.com/la/book/9783319737638
– Deftu AT, Radu BM, Cretoiu D, Deftu AF, Cretoiu SM, Xiao J. 2020. Exosomes as intercellular communication messengers for cardiovascular and cerebrovascular diseases, in Exosomes. A Clinical Compendium., Elsevier, editors Larry Edelstein and Denis Noble, ISBN: 978-0-12-816053-4, https://www.sciencedirect.com/science/article/pii/B9780128160534000092
International scientific communications resulted from the project
– Stefan Mann, Juliane Heide, Beatrice Radu, Bogdan Amuzescu, Thomas Knott, „Measuring Multiple Ion Current Components in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes via Automated Patch-Clamp”, SPS2017 Annual Meeting – Safety Pharmacology Society, Berlin, Germany, September 24-27, 2017, poster
– Thomas Knott, Stefan Mann, Juliane Heide, Razvan Airini, Florin Bogdan Epureanu, Alexandru Deftu, Antonia Teona Deftu, Beatrice Mihaela Radu, Bogdan Amuzescu, „Recording and modeling multiple ion current components and action potentials in human induced pluripotent stem cell-derived cardiomyocytes”, 62nd Annual Meeting of the Biophysical Society. February 17-21, 2018, San Frascisco, California, poster
– Stefan Mann, Juliane Heide, Răzvan Airini, Florin Epureanu, Alexandru Deftu, Antonia Teona Deftu, Beatrice Mihaela Radu, Thomas Knott, Bogdan Amuzescu, ”Development of a New CiPA-Compliant MOA In Vitro Assay on Stem Cell-Derived Cardiomyocytes including Automated Data Analysis and Model Parameter Optimization”, Pharmacology Annual Meeting 2018, 30 sep – 4 oct 2018, Washington DC, Statele Unite ale Americii, poster
– Stefan Mann, Juliane Heide, Razvan Airini, Florin Epureanu, Alexandru Deftu, Antonia Teona Deftu, Beatrice Mihaela Radu, Thomas Knott, Bogdan Amuzescu, ”Development of a New CiPA-compliant Cardiac Safety Pharmacology Automated Patch-clamp Assay”, Ncardia Application Workshop, 7-9 noiembrie 2018, Cologne, Germany, poster
– Amuzescu BP, Knott T, Mann SA, Knuepling J, Airini R, Epureanu FB, Radu BM, Using onset-of-block kinetic analysis of hERG1 current with a Markov model to improve in silico proarrhythmogenic risk prediction, 64th Annual Meeting of the Biophysical Society, Februarie 15-19, 2020, San Diego, California, USA, poster
National scientific communications resulted from the project
– Răzvan Airini, Alexandru-Florian Deftu, Florin Bogdan Epureanu, Dan Florin Mihăilescu, Bogdan Amuzescu, „Blocarea canalelor de potasiu HERG cu ajutorul compusului E-4031 prin experimente de patch-clamp clasic și automat”, Session of Scientific Communications of the Faculty of Biology – 2017, Faculty of Biology, University of Bucharest, June 2, 2017, oral presentation
– Răzvan Airini, Alexandru-Florian Deftu, Florin Bogdan Epureanu, Bogdan Amuzescu, „Comparison between automated and manual patch-clamp platforms in assessment of proarrhyhmogenic effects of drugs via hERG channels blockade”, The Annual Scientific Meeting of The Faculty of Physics, Section of Biophysics. Medical physics, Room 8, Biophysics Laboratory, Faculty of Physics, University of Bucharest, June 23, 2017, oral presentation
– Răzvan Airini, Florin Iordache, Dorin Alexandru, Lorand Savu, Florin Epureanu, Dan F. Mihăilescu, Bogdan Amuzescu, Horia Maniu, Investigation of the phenomenon of cellular senescence in amniotic fluid stem cells, Session of Scientific Communications of the Faculty of Biology, Bucharest, May 19, 2018, oral presentation
– B. Amuzescu, R. Airini, F. Epureanu, A.F. Deftu, A.T. Deftu, B. Radu, D.F. Mihailescu, S. Mann, J. Heide, T. Knott, Automated data analysis and optimization algorithms for electrophysiology and pharmacology studies on human induced pluripotent stem cell-derived cardiomyocytes, The Annual Scientific Conference of the Faculty of Physics, Bucharest-Măgurele, June 21-22, 2018, oral presentation
– Airini Răzvan, Iordache Florin, Alexandru Dorin, Savu Lorand, Epureanu Florin, Mihailescu Dan Florin, Amuzescu Bogdan, Maniu Horia, Senescence changes in mesenchymal stem cells cultures, The Annual Scientific Conference of the Faculty of Physics, Bucharest-Măgurele, June 21-22, 2018, oral presentation
– Bogdan Amuzescu, A New CiPA-compliant cardiac safety pharmacology automated patch-clamp assay on Cor-4U® cardiomyocytes, XVth edition of the National Conference of the Society of Pure and Applied Biophysics, September 7-9, 2018, Bucharest, oral presentation
– Răzvan Airini, Changes induced by senescence in human amniotic fluid stem cells, XVth edition of the National Conference of the Society of Pure and Applied Biophysics, September 7-9, 2018, Bucharest, oral presentation
– F. Epureanu, R. Airini, A.F. Deftu, A.T. Deftu, B. Radu, D.F. Mihailescu, S. Mann, J. Heide, T. Knott, B. Amuzescu, Development of a complex assay for measurement of multiple ion current components and action potentials on human induced pluripotent stem cell-derived cardiomyocytes, XVth edition of the National Conference of the Society of Pure and Applied Biophysics, September 7-9, 2018, Bucharest, poster
– Antonia-Teona Deftu, Bogdan Amuzescu, ”Protective effects of Nanosof on different cultured cells exposed to H2O2”, XVth edition of the National Conference of the Society of Pure and Applied Biophysics, September 7-9, 2018, Bucharest, poster
– Bogdan Amuzescu, Pauline Le Goc, Razvan Airini, Florin Bogdan Epureanu, Alexandru Florian Deftu, Antonia Teona Deftu, Beatrice Radu, Dan Florin Mihailescu, Analysis of proarrhythmogenic rick predictors using advanced cardiomyocyte electrophysiology models combined with experimental pharmacology data on human cardiac ion channels in heterologous expression systems and induced pluripotent stem cell-derived cardiomyocytes, Annual Scientific Conference of the Faculty of Physics, University of Bucharest, June 21-22, 2019, Romania, oral presentation
– Bogdan Amuzescu, Bogdan Florin Epureanu, Florin Iordache, Antonia Teona Deftu, Razvan Airini, Dorin Alexandrescu, Lorand Savu, Dan Florin Mihailescu, Horia Maniu, Expression of pluripotency, surface and senescence markers in human amniocytes and in vitro induction of neural progenitor formation, Annual Scientific Conference of the Faculty of Physics, University of Bucharest, June 21-22, 2019, Romania, oral presentation